FACTS ABOUT KETAMINE QT PROLONGATION REVEALED

Metabolism Ketamine is metabolized by means of N-dealkylation for the active metabolite norketamine largely by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of the cyclohexone ring to form hydroxynorketamine compounds via CYP-dependent pathways, which are conjugated with glucuronic acid and subs